The formulation of nanomedicines for treating tuberculosis

A Costa, M Pinheiro, J Magalhães, R Ribeiro… - Advanced drug delivery …, 2016 - Elsevier
Recent estimates indicate that tuberculosis (TB) is the leading cause of death worldwide,
alongside the human immunodeficiency virus (HIV) infection. The current treatment is …

Delivering drugs to the lungs: The history of repurposing in the treatment of respiratory diseases

SP Newman - Advanced drug delivery reviews, 2018 - Elsevier
The repurposing of drug delivery by the pulmonary route has been applied to treatment and
prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been …

The role of bacterial biofilms in chronic infections

T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

An inhalable theranostic system for local tuberculosis treatment containing an isoniazid loaded metal organic framework Fe-MIL-101-NH2—from raw MOF to drug …

G Wyszogrodzka-Gaweł, P Dorożyński, S Giovagnoli… - Pharmaceutics, 2019 - mdpi.com
The theranostic approach to local tuberculosis treatment allows drug delivery and imaging of
the lungs for a better control and personalization of antibiotic therapy. Metal-organic …

Dry powder inhalable formulations for anti-tubercular therapy

T Parumasivam, RYK Chang, S Abdelghany… - Advanced drug delivery …, 2016 - Elsevier
Tuberculosis (TB) is an intracellular infectious disease caused by the airborne bacterium,
Mycobacterium tuberculosis. Despite considerable research efforts, the treatment of TB …

High dose dry powder inhalers to overcome the challenges of tuberculosis treatment

MAM Momin, IG Tucker, SC Das - International journal of pharmaceutics, 2018 - Elsevier
Tuberculosis (TB) is a major global health burden. The emergence of the human
immunodeficiency virus (HIV) epidemic and drug resistance has complicated global TB …

Inhaled dry powder formulations for treating tuberculosis

S Das, I Tucker, P Stewart - Current Drug Delivery, 2015 - ingentaconnect.com
Tuberculosis is the second leading cause of death from infectious diseases. Although
antitubercular drugs have been traditionally administered orally, there is a growing interest …

Cationic inhalable particles for enhanced drug delivery to M. tuberculosis infected macrophages

PR Sharma, AA Dravid, YC Kalapala, VK Gupta… - Biomaterials …, 2022 - Elsevier
Inhalable microparticle-based drug delivery platforms are being investigated extensively for
Tuberculosis (TB) treatment as they offer efficient deposition in lungs and improved …

Nanoparticle-mediated macrophage targeting—a new inhalation therapy tackling tuberculosis

S Makled, N Boraie, N Nafee - Drug Delivery and Translational Research, 2021 - Springer
Despite the potent clinical efficacy of linezolid (LNZ) against drug-resistant tuberculosis, its
safety and tolerability remain of major concern. Our objective is to develop antitubercular …

Opportunities and challenges for host-directed therapies in tuberculosis

M Sachan, A Srivastava, R Ranjan… - Current …, 2016 - ingentaconnect.com
Background: Tuberculosis (TB) ranks alongside the human immunodeficiency virus (HIV) as
cause of death due to an infectious disease. Recently, host-targeted therapies (HDT) have …