Fibroblast growth factors (FGF) and their receptors serve many functions in both the
developing and adult organism. Humans contain 18 FGF ligands and four FGF receptors …

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth
factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic …

Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and,
given the druggable nature of these enzymes, an attractive target for anticancer therapy …

Fibroblast growth factor receptors (FGFRs) play diverse roles in the control of cell
proliferation, cell differentiation, angiogenesis and development. Activating the mutations of …

Receptor tyrosine kinases (RTKs) are a family of ligand-binding cell surface receptors that
regulate a wide range of essential cellular activities, including proliferation, differentiation …

Five main factors play a pivotal role in the pathogenesis of acne: androgen dependence,
follicular retention hyperkeratosis, increased sebaceous lipogenesis, increased colonization …

Oral isotretinoin (13-cis retinoic acid) is the most effective drug in the treatment of acne and
restores all major pathogenetic factors of acne vulgaris. Isotretinoin is regarded as a prodrug …

The fibroblast growth factor receptor 2 (FGFR 2) gene is one of the most extensively studied
genes with many known mutations implicated in several human disorders, including …

More than ten thousand peer‐reviewed studies have assessed the role of fibroblast growth
factors (FGFs) and their receptors (FGFRs) in cancer, but few patients have yet benefited …

FGFR Craniosynostosis Syndromes Overview - GeneReviews® - NCBI Bookshelf US flag An
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