Type 2 diabetes mellitus (T2DM) is one of the most risk factors threatening human health.
Although genetic and environmental factors contribute to the development of T2DM, gut …

Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Although microplastic (MP) pollution has recently garnered increasing attention, few studies
have examined the effects of these small particles on the vascular system. Therefore, the …

Depression is a risk factor for Alzheimer's (AD) and cardiovascular diseases (CVD).
Therefore, depression treatment restricts its deteriorating effects on mood, memory and CV …

Dyskinesia is characterized by abnormal involuntary movements (AIMs). Such movements
are considered restrictive problem associated with the chronic use of L-dopa in Parkinson's …

Introduction: Cholestasis is the stoppage of bile flow, leading to the accumulation of
potentially cytotoxic bile components in the liver. These cytotoxic molecules affect many …

Gut microbiota dysbiosis has been reported as a risk factor in the development of type 2
diabetes mellitus (T2DM). Polysaccharides from Phellinus igniarius (P. igniarius) possess …

Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes mellitus, and
inflammatory pathways have been linked to its pathogenesis. In this retrospective …

Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism
and functional mitochondria to keep ATP levels in physiological range. Imbalances in …

Geraniol (GE), an important ingredient in several essential oils, displayed pleiotropic
biological activities through targeting multiple signaling cascades. In the current study, we …