Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …

Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

Immunotherapy has emerged as a major therapeutic modality in oncology. Currently,
however, the majority of patients with cancer do not derive benefit from these treatments …

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …