Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
VS Sohal, JLR Rubenstein - Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
Development and functional diversification of cortical interneurons
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …
collection of cell types that are characterized by their unique spatial and temporal …
[HTML][HTML] Single-cell multi-omic integration compares and contrasts features of brain cell identity
Defining cell types requires integrating diverse single-cell measurements from multiple
experiments and biological contexts. To flexibly model single-cell datasets, we developed …
experiments and biological contexts. To flexibly model single-cell datasets, we developed …
Genetics of glutamate and its receptors in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …
deficits in social interaction skills, impaired communication, and repetitive and restricted …
Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
Transplantation of dopaminergic neurons can potentially improve the clinical outcome of
Parkinson's disease, a neurological disorder resulting from degeneration of mesencephalic …
Parkinson's disease, a neurological disorder resulting from degeneration of mesencephalic …
[HTML][HTML] Ultraconserved enhancers are required for normal development
Non-coding" ultraconserved" regions containing hundreds of consecutive bases of perfect
sequence conservation across mammalian genomes can function as distant-acting …
sequence conservation across mammalian genomes can function as distant-acting …
OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of down syndrome
Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in
DS patients may arise from imbalances in excitatory and inhibitory neurotransmission …
DS patients may arise from imbalances in excitatory and inhibitory neurotransmission …
[HTML][HTML] A high-resolution enhancer atlas of the developing telencephalon
The mammalian telencephalon plays critical roles in cognition, motor function, and emotion.
Though many of the genes required for its development have been identified, the distant …
Though many of the genes required for its development have been identified, the distant …
CXCR4 and CXCR7 have distinct functions in regulating interneuron migration
Y Wang, G Li, A Stanco, JE Long, D Crawford… - Neuron, 2011 - cell.com
CXCL12/CXCR4 signaling is critical for cortical interneuron migration and their final laminar
distribution. No information is yet available on CXCR7, a newly defined CXCL12 receptor …
distribution. No information is yet available on CXCR7, a newly defined CXCL12 receptor …