Human septins comprise a family of 13 genes that encode for> 30 protein isoforms with
ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble …

Septin GTPases form nonpolar heteropolymers that play important roles in cytokinesis and
other cellular processes. The ability to form heteropolymers appears to be critical to many …

Septins are GTP-binding and membrane-interacting proteins with a highly conserved
domain structure involved in various cellular processes, including cytoskeleton organization …

Septins are a family of cytoskeleton related proteins consisting of 14 members that associate
and interact with actin and tubulin. From yeast to humans, septins maintain a conserved role …

Background Septins belong to the GTPase superclass of proteins and have been
functionally implicated in cytokinesis and the maintenance of cellular morphology. They are …

The assembly of a septin filament requires that homologous monomers must distinguish
between one another in establishing appropriate interfaces with their neighbors. To …

Septins are an evolutionarily conserved family of GTPases with diverse functions including
roles in cytokinesis that have been implicated in neoplasia. To address the potential role of …

Human septins 3, 9 and 12 are the only members of a specific subgroup of septins that
display several unusual features, including the absence of a C-terminal coiled coil. This …

Mammalian septins comprise a family of 13 genes that encode GTP-binding proteins.
Specific combinations of septins can hetero-oligomerize and form filaments in vivo and in …

Glioblastoma (GBM) is the most common primary malignancy of the central nervous system
(CNS) with< 10% 5-year survival rate. The growth and invasion of GBM cells into normal …