Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …

The glucocorticoid receptor (GR) is a bona fide ligand‐regulated transcription factor. Cloned
in the 80s, the GR has become one of the best‐studied and clinically most relevant members …

Background Histone lactylation has been recently described as a novel histone post-
translational modification linking cellular metabolism to epigenetic regulation. Results Given …

Androgens are a class of steroid hormones primarily associated with male sexual
development and physiology, but exert pleiotropic effects in either sex. They have a crucial …

MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role
in regulating myogenesis during muscle development and regeneration. However, whether …

Peripheral nerve injury is common, and can lead to skeletal muscle atrophy and dysfunction.
However, the underlying molecular mechanisms are not fully understood. The transcription …

Background Mammalian skeletal muscles consist of two main fibre types: slow‐twitch (type I,
oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre …

Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat
chronic inflammation and autoimmune disorders. However, long-term treatments are limited …

Glucocorticoids (GCs) are widely used therapeutic agents to treat a broad range of
inflammatory conditions. Their functional effects are elicited by binding to the glucocorticoid …

The glucocorticoid receptor (GR) is a major nuclear receptor (NR) drug target for the
treatment of inflammatory disorders and several cancers. Despite the effectiveness of GR …