Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Adolescent brain maturation is characterized by the emergence of executive function
mediated by the prefrontal cortex, eg, goal planning, inhibition of impulsive behavior and set …

An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS
revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the …

The cellular mechanisms underlying functional hyperemia—the coupling of neuronal
activation to cerebral blood vessel responses—are not yet known. Here we show in rat …

Abstract Hebb's rule (1949) states that learning and memory are based on modifications of
synaptic strength among neurons that are simultaneously active. This implies that enhanced …

ACTIVATION of the N-methyl-d-aspartate (NMDA) receptor is important for certain forms of
activity-dependent synaptic plasticity, such as long-term potentiation (reviewed in ref. 1), and …

The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

Maturation of the visual cortex is influenced by visual experience during an early postnatal
period. The factors that regulate such a critical period remain unclear. We examined the …

In the mature brain, GABA (γ-aminobutyric acid) functions primarily as an inhibitory
neurotransmitter. But it can also act as a trophic factor during nervous system development …

The precise subunit composition of synaptic ionotropic receptors in the brain is poorly
understood. This information is of particular importance with regard to AMPA-type glutamate …