An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …

Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …

We report the identification of multitarget anti-Alzheimer compounds designed by combining
a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
characterized by the primary risk factor, age. Several attempts have been made to treat AD …

Family physicians play a crucial role in the management and ongoing care of patients with
Alzheimer disease (AD). This article reviews the effects of nonpharmacologic and …

In this work, we describe the synthesis and in vitro evaluation of a novel series of multitarget-
directed ligands (MTDL) displaying both nanomolar dual-binding site (DBS) …

Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …

Protein misfolding and aggregation has been related to several human disorders, generally
termed protein aggregation diseases. These diseases include neurodegenerative disorders …

In this work, we review and comment upon the challenges and the 'quo vadis' in Alzheimer's
disease drug discovery at the beginning of the new millennium. We emphasize recent …