A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

J Anjum, S Mitra, R Das, R Alam, A Mojumder… - Pharmacological …, 2022 - Elsevier
Abnormalities in the mitogen-activated protein kinase (MAPK) signaling pathway are a key
contributor to the carcinogenesis process and have therefore been implicated in several …

[HTML][HTML] An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

Z Hu, Y Guan, W Hu, Z Xu, M Ishfaq - Iranian Journal of Basic …, 2022 - ncbi.nlm.nih.gov
The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties
and are mainly found in the roots of Oroxylum indicum (L.) Kurz and Scutellaria baicalensis …

Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro

W Yan, X Ma, X Zhao, S Zhang - Drug design, development and …, 2018 - Taylor & Francis
Purpose Baicalein, a widely used Chinese herbal medicine, has shown anticancer effects
on many types of human cancer cell lines. However, little is known about the underlying …

[HTML][HTML] Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology, molecular docking …

F Hou, Z Yu, YH Cheng, Y Liu, S Liang, F Zhang - Phytomedicine, 2022 - Elsevier
Background Oral leukoplakia (OLK), an uncharacterized pathological condition that occurs
as a white patch in the oral mucosa, is the most common precancerous condition. Scutellaria …

Role of plant-derived active constituents in cancer treatment and their mechanisms of action

AW Khan, M Farooq, M Haseeb, S Choi - Cells, 2022 - mdpi.com
Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

Therapeutic potential of Scutellaria baicalensis Georgi in lung cancer therapy

L Xiang, Y Gao, S Chen, J Sun, J Wu, X Meng - Phytomedicine, 2022 - Elsevier
Background Globally, lung cancer is the leading cause of cancer associated mortalities. The
current conventional chemotherapy remains the preferred treatment option for lung cancer …

A comprehensive and current review on the role of flavonoids in lung cancer–Experimental and theoretical approaches

Ş Berk, S Kaya, EK Akkol, H Bardakçı - Phytomedicine, 2022 - Elsevier
Background It is well-known that flavonoids, which can be easily obtained from many fruits
and vegetables are widely preferred in the treatment of some important diseases. Some …

Flavones: Six selected flavones and their related signaling pathways that induce apoptosis in cancer

SH Jeong, HH Kim, SE Ha, MY Park… - International Journal of …, 2022 - mdpi.com
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and
takes many lives. Apoptosis is a programmed cell death mechanism and if it does not …

Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

N Chandrashekar, A Pandi - Journal of Food Biochemistry, 2022 - Wiley Online Library
Plant‐derived flavonoids are reported to function as potential anti‐cancer agents against
different types of cancer. Baicalein (BE) is an important flavonoid found in the roots of …

The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model

ZSJ Liu, TTT Truong, CC Bortolasci, B Spolding… - Molecular …, 2024 - nature.com
Baicalin is a flavone glycoside derived from flowering plants belonging to the Scutellaria
genus. Previous studies have reported baicalin's anti-inflammatory and neuroprotective …