This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

There is increasing evidence that nitric oxide (NO), a free radical that can act both as a
signaling molecule and a neurotoxin, is involved in the mechanisms of cerebral ischemia …

Neuronal connections and cortical maps are continuously remodeled by our experience.
Knowledge of the potential capabilityof the brain to compensate for lesions is a prerequisite …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of the nuclear hormone receptor superfamily. The 3 PPAR isoforms (alpha, delta/beta …

Cardiac arrest is an important public health issue, with a survival rate of approximately 15 to
22%. A great proportion of these deaths occur after resuscitation due to post-cardiac arrest …

Brain ischemia triggers a complex cascade of molecular events that unfolds over hours to
days. Identified mechanisms of postischemic neuronal injury include altered Ca2+ …

With the emergence of novel technologies and ground breaking concepts in BBB basic
research in the past decades, the researchers' attention on the critical role of blood brain …

The flow of new information on gene expression related to apoptosis has been relentless in
the last several years. This has also been the case with respect to gene expression after …

The mechanisms underlying secondary or delayed cell death following traumatic brain injury
(TBI) are poorly understood. Recent evidence from experimental models of TBI suggest that …

Focal brain lesions can lead to metabolic and structural changes in areas distant from but
connected to the lesion site. After focal ischemic or excitotoxic lesions of the cortex and/or …