The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

The aggregation of proteins is of fundamental relevance in a number of daily phenomena,
as important and diverse as blood coagulation, medical diseases, or cooking an egg in the …

We develop a detailed description of protein translational and rotational diffusion in
concentrated solution on the basis of all-atom molecular dynamics simulations in explicit …

The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …

The interaction of the globular protein lysozyme with silica nanoparticles of diameter 20 nm
was studied in a pH range between the isoelectric points (IEPs) of silica and the protein (pH …

Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. It is hypothesized
that some concentrated mAb solutions exhibit formation of a solution phase consisting of …

Aside from polymerization techniques, polymer nanoparticles can be generated through the
displacement of a solvent with a nonsolvent, ie, nanoprecipitation. In this study, we utilize a …

The stability and activity of a model protein, lysozyme, in 1: 2 choline chloride: glycerol was
characterised across a wide range of protein concentrations, ie, between 4 and 143 mg ml …

For a long time, the effect of a crowded cellular environment on protein dynamics has been
largely ignored. Recent experiments indicate that proteins diffuse more slowly in a living cell …

Viscosity of protein solution is one of the most troublesome issues for the high-concentration
formulation of protein drugs. In this review, we summarize the practical methods that …