Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Cells undergo a major epigenome reconfiguration when reprogrammed to human induced
pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human …

It is extremely rare for a single experiment to be so impactful and timely that it shapes and
forecasts the experiments of the next decade. Here, we review how two such experiments …

DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …

Introduction: Our previous scientometric review of regenerative medicine provides a
snapshot of the fast-growing field up to the end of 2011. The new review identifies emerging …

The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity
back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset …

Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is
inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell …

The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …