Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Why do we get cancer mostly when we are old? According to current paradigms, the answer
is simple: mutations accumulate in our tissues throughout life, and some of these mutations …

Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive
oxygen species; it is considered as one of the prominent factors in slowing down and …

This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

A dose-response relationship to stressors, according to the hormesis theory, is characterized
by low-dose stimulation and high-dose inhibition. It is non-linear with a low-dose optimum …

Aging is a major risk factor to develop neurodegenerative diseases and is associated with
decreased buffering capacity of the proteostasis network. We investigated the significance of …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …