Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

The principles and applications of time‐of‐flight mass spectrometry involving instruments
with independent (orthogonal) axes for ion generation and mass analysis are reviewed. This …

Abstract Time‐of‐flight (TOF) mass spectrometers have become the instruments of choice
where high molecular masses must be measured. Pulsed extraction, orthogonal extraction …

Antibodies, also known as immunoglobulins, have emerged as one of the most promising
classes of therapeutics in the biopharmaceutical industry. The need for complete …

A new delayed extraction matrix‐assisted laser desorption/ionization (MALDI) time‐of‐flight
(TOF) mass spectrometer system is described which provides dramatically improved …

A method is described for improving the sensitivity of peptide mapping with electrospray
liquid chromatography-mass spectrometry using trifluoroacetic acid (TFA) containing HPLC …

This industrially relevant resource covers all established and emerging analytical methods
for the deformulation of polymeric materials, with emphasis on the non-polymeric …

The design of new therapeutic molecules can be significantly informed by studying protein-
ligand interactions using biophysical approaches directly after purification of the protein …

In the past few years, the instrumental developments in the field of combined liquid
chromatography–mass spectrometry (LC–MS) and related liquid-introduction techniques …

As we enter the 21st century, the practice of mass spectrometry has been making ever
broadening contributions to our understanding of nature for slightly over 100 years. The …