Opportunities and obstacles for deep learning in biology and medicine

T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

[HTML][HTML] Natural language processing of clinical notes on chronic diseases: systematic review

S Sheikhalishahi, R Miotto, JT Dudley… - JMIR medical …, 2019 - medinform.jmir.org
Background: Novel approaches that complement and go beyond evidence-based medicine
are required in the domain of chronic diseases, given the growing incidence of such …

A roadmap for foundational research on artificial intelligence in medical imaging: from the 2018 NIH/RSNA/ACR/The Academy Workshop

CP Langlotz, B Allen, BJ Erickson, J Kalpathy-Cramer… - Radiology, 2019 - pubs.rsna.org
Imaging research laboratories are rapidly creating machine learning systems that achieve
expert human performance using open-source methods and tools. These artificial …

Biological phenotyping in sepsis and acute respiratory distress syndrome

P Sinha, NJ Meyer, CS Calfee - Annual review of medicine, 2023 - annualreviews.org
Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …

Model-assisted cohort selection with bias analysis for generating large-scale cohorts from the EHR for oncology research

B Birnbaum, N Nussbaum, K Seidl-Rathkopf… - arXiv preprint arXiv …, 2020 - arxiv.org
Objective Electronic health records (EHRs) are a promising source of data for health
outcomes research in oncology. A challenge in using EHR data is that selecting cohorts of …

The GA4GH Phenopacket schema defines a computable representation of clinical data

JOB Jacobsen, M Baudis, GS Baynam… - Nature …, 2022 - nature.com
TG is a shareholder of Westlake Omics Inc. TI is a cofounder of Data4Cure, is on the
Scientific Advisory Board and has an equity interest. TI is on the Scientific Advisory Board of …

A machine learning-based framework to identify type 2 diabetes through electronic health records

T Zheng, W Xie, L Xu, X He, Y Zhang, M You… - International journal of …, 2017 - Elsevier
Objective To discover diverse genotype-phenotype associations affiliated with Type 2
Diabetes Mellitus (T2DM) via genome-wide association study (GWAS) and phenome-wide …

Big data analytics to improve cardiovascular care: promise and challenges

JS Rumsfeld, KE Joynt, TM Maddox - Nature Reviews Cardiology, 2016 - nature.com
The potential for big data analytics to improve cardiovascular quality of care and patient
outcomes is tremendous. However, the application of big data in health care is at a nascent …

PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability

JC Kirby, P Speltz, LV Rasmussen… - Journal of the …, 2016 - academic.oup.com
Objective Health care generated data have become an important source for clinical and
genomic research. Often, investigators create and iteratively refine phenotype algorithms to …

Artificial intelligence approaches using natural language processing to advance EHR-based clinical research

Y Juhn, H Liu - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
The wide adoption of electronic health record systems in health care generates big real-
world data that open new venues to conduct clinical research. As a large amount of valuable …