Cellular and molecular players in the tumor microenvironment of renal cell carcinoma

F Lasorsa, M Rutigliano, M Milella, M Ferro… - Journal of Clinical …, 2023 - mdpi.com
Globally, clear-cell renal cell carcinoma (ccRCC) represents the most prevalent type of
kidney cancer. Surgery plays a key role in the treatment of this cancer, although one third of …

Update on adipose tissue and cancer

KA Brown, PE Scherer - Endocrine reviews, 2023 - academic.oup.com
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

The tumour microenvironment and metabolism in renal cell carcinoma targeted or immune therapy

Y Lai, F Tang, Y Huang, C He, C Chen… - Journal of cellular …, 2021 - Wiley Online Library
Renal cell carcinoma (RCC) is one of the most common tumours of the urinary system, and
is insidious and not susceptible to chemoradiotherapy. As the most common subtype of RCC …

A hint for the obesity paradox and the link between obesity, perirenal adipose tissue and Renal Cell Carcinoma progression

J Preza-Fernandes, P Passos, M Mendes-Ferreira… - Scientific Reports, 2022 - nature.com
Increasing evidence supports a role for local fat depots in cancer outcomes. Despite the
robust positive association of obesity with renal cell carcinoma (RCCa) diagnosis, increased …

Renal peritumoral adipose tissue undergoes a browning process and stimulates the expression of epithelial-mesenchymal transition markers in human renal cells

M Ferrando, FA Bruna, LR Romeo, D Contador… - Scientific Reports, 2022 - nature.com
Tumor cells can interact with neighboring adipose cells and adipocyte dedifferentiation
appears to be an important aspect of tumorigenesis. We evaluated the size of adipocytes in …

Body mass index in patients treated with cabozantinib for advanced renal cell carcinoma: a new prognostic factor?

M Santoni, F Massari, S Bracarda, G Procopio… - Diagnostics, 2021 - mdpi.com
We analyzed the clinical and pathological features of renal cell carcinoma (RCC) patients
treated with cabozantinib stratified by body mass index (BMI). We retrospectively collected …

Quantitative proteomics identifies secreted diagnostic biomarkers as well as tumor-dependent prognostic targets for clear cell renal cell carcinoma

A Senturk, AT Sahin, A Armutlu, MC Kiremit… - Molecular cancer …, 2021 - AACR
Clear cell renal cell carcinoma (ccRCC) is the third most common and most malignant
urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors …

The prognostic role of perirenal fat tissue in non-metastatic renal cell carcinoma

MS Beşler, E Ölçücüoğlu, E Ölçücüoğlu - Japanese Journal of Radiology, 2024 - Springer
Purpose The aim of this study was to evaluate the impact of perirenal fat volume and
perirenal fat density on prognosis in surgically treated non-metastatic renal cell carcinomas …

Hypothyroidism and Mammary Cancer: Role of Peritumoral Adipose Tissue

L Zyla, FE Santiano, F Bruna, S Gómez, R Cano… - 2023 - researchsquare.com
To study the effects of HypoT on rat mammary tumor-associated adipose tissue and its ability
to modify the biological behavior of breast cancer epithelial cells, we evaluated changes in …

Perirenal White Adipose Tissue Browning and Epithelial-Mesenchymal Transition, Contributes To Tumor Development in Kidney Cancer

M Ferrando, F Bruna, L Romeo, D Contador… - 2021 - researchsquare.com
Tumor cells can interact with neighboring adipose tissue and adipocyte dedifferentiation
appears to be an important aspect of tumorigenesis. We evaluated the size of adipocytes in …