Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …

Triple negative breast cancer (TNBC) is characterized by the lack of estrogen and
progesterone receptor expression and lacks HER2 overexpression or gene amplification. It …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Mutation of the TP53 tumor suppressor gene is the most common genetic alteration in
cancer, and almost 1000 alleles have been identified in human tumors. While virtually all …

Histopathological grading of epithelial dysplasia remains the principal laboratory method for
assessing the risk of malignant transformation in oral potentially malignant disorders …