p53 in ferroptosis regulation: the new weapon for the old guardian
Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
Regulatory mechanism of MicroRNA expression in cancer
Z Ali Syeda, SSS Langden, C Munkhzul, M Lee… - International journal of …, 2020 - mdpi.com
Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …
Advances in multiplexed techniques for the detection and quantification of microRNAs
MicroRNA detection is currently a crucial analytical chemistry challenge: almost 2000
papers were referenced in PubMed in 2018 and 2019 for the keywords “miRNA detection …
papers were referenced in PubMed in 2018 and 2019 for the keywords “miRNA detection …
[HTML][HTML] MicroRNA: A signature for cancer progression
MicroRNAs (miRNAs) are a group of small non-coding RNAs that post-transcriptionally
control expression of genes by targeting mRNAs. miRNA alterations partake in the …
control expression of genes by targeting mRNAs. miRNA alterations partake in the …
Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets
Multiple studies suggested using different miRNAs as biomarkers for prognosis of
hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database …
hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database …
The liver as an endocrine organ—linking NAFLD and insulin resistance
MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …
function in tumour suppression, p53 also plays a major role in the response of malignant as …