Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522
KK Ang, Q Zhang, DI Rosenthal… - Journal of clinical …, 2014 - ascopubs.org
Purpose Combining cisplatin or cetuximab with radiation improves overall survival (OS) of
patients with stage III or IV head and neck carcinoma (HNC). Cetuximab plus platinum …
patients with stage III or IV head and neck carcinoma (HNC). Cetuximab plus platinum …
Targeting the EGFR signaling pathway in cancer therapy
P Seshacharyulu, MP Ponnusamy… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …
recently been made, wherein EGFR and its family members have emerged as useful …
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
DL Wheeler, EF Dunn, PM Harari - Nature reviews Clinical oncology, 2010 - nature.com
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Expression and function of the epidermal growth factor receptor in physiology and disease
J Chen, F Zeng, SJ Forrester, S Eguchi… - Physiological …, 2016 - journals.physiology.org
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
Epidermal growth factor receptor biology in head and neck cancer
S Kalyankrishna, JR Grandis - Journal of clinical oncology, 2006 - ascopubs.org
Epidermal growth factor receptor (EGFR) is overexpressed in several epithelial
malignancies, including head and neck squamous cell carcinoma (HNSCC), which exhibits …
malignancies, including head and neck squamous cell carcinoma (HNSCC), which exhibits …
Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment
The prototypic head and neck squamous cell carcinoma (HNSCC) arises from the mucosal
lining of the upper aerodigestive tract, demonstrates squamous differentiation …
lining of the upper aerodigestive tract, demonstrates squamous differentiation …
EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
Purpose To prospectively identify markers of response to therapy and outcome in an organ-
sparing trial for advanced oropharyngeal cancer. Patients and Methods Pretreatment …
sparing trial for advanced oropharyngeal cancer. Patients and Methods Pretreatment …
Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
Purpose High epidermal growth factor receptor (EGFR) gene copy number is associated
with poor prognosis in lung cancer, but such findings have not been reported for HNSCC. A …
with poor prognosis in lung cancer, but such findings have not been reported for HNSCC. A …