Disrupted skeletal muscle mitochondrial dynamics, mitophagy, and biogenesis during cancer cachexia: a role for inflammation
BN VanderVeen, DK Fix… - Oxidative medicine and …, 2017 - Wiley Online Library
Chronic inflammation is a hallmark of cancer cachexia in both patients and preclinical
models. Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20 …
models. Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20 …
Phenotypic features of cancer cachexia‐related loss of skeletal muscle mass and function: lessons from human and animal studies
A Martin, D Freyssenet - Journal of cachexia, sarcopenia and …, 2021 - Wiley Online Library
Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …
Modeling human cancer-induced cachexia
EE Talbert, MC Cuitiño, KJ Ladner, PV Rajasekerea… - Cell reports, 2019 - cell.com
Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In
cancer, cachexia is associated with increased morbidity and mortality and decreased …
cancer, cachexia is associated with increased morbidity and mortality and decreased …
[HTML][HTML] Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass
Age-related loss of skeletal muscle mass and contractile dysfunction, or sarcopenia, reduces
independence and quality of life in the elderly and leads to increased risk of comorbidities …
independence and quality of life in the elderly and leads to increased risk of comorbidities …
Neuromuscular fatigue during exercise: Methodological considerations, etiology and potential role in chronic fatigue
The term fatigue is used to describe a distressing and persistent symptom of physical and/or
mental tiredness in certain clinical populations, with distinct but ultimately complex …
mental tiredness in certain clinical populations, with distinct but ultimately complex …
Skeletal muscle deconditioning in breast cancer patients undergoing chemotherapy: current knowledge and insights from other cancers
Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and
adjuvant chemotherapies are extensively used in order to reduce tumor development and …
adjuvant chemotherapies are extensively used in order to reduce tumor development and …
HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy
AW Beharry, PB Sandesara, BM Roberts… - Journal of cell …, 2014 - journals.biologists.com
ABSTRACT The Forkhead box O (FoxO) transcription factors are activated, and necessary
for the muscle atrophy, in several pathophysiological conditions, including muscle disuse …
for the muscle atrophy, in several pathophysiological conditions, including muscle disuse …
Combination of exercise training and erythropoietin prevents cancer-induced muscle alterations
Cancer cachexia is a syndrome characterized by loss of skeletal muscle mass, inflammation,
anorexia and anemia, contributing to patient fatigue and reduced quality of life. In addition to …
anorexia and anemia, contributing to patient fatigue and reduced quality of life. In addition to …
Understanding the role of exercise in cancer cachexia therapy
Cachexia, the unintentional loss of body weight, is prevalent in many cancer types, and the
associated skeletal muscle mass depletion increases patient morbidity and mortality. While …
associated skeletal muscle mass depletion increases patient morbidity and mortality. While …
Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia
Background Evidence from cachectic cancer patients and animal models of cancer cachexia
supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer …
supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer …