Development, wiring and function of dopamine neuron subtypes
O Garritsen, EY van Battum, LM Grossouw… - Nature Reviews …, 2023 - nature.com
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …
Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …
[HTML][HTML] ALDH1A1 in cancers: bidirectional function, drug resistance, and regulatory mechanism
H Yue, Z Hu, R Hu, Z Guo, Y Zheng, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Aldehyde dehydrogenases 1 family member A1 (ALDH1A1) gene codes a cytoplasmic
enzyme and shows vital physiological and pathophysiological functions in many areas …
enzyme and shows vital physiological and pathophysiological functions in many areas …
Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction
Abstract Endocannabinoid (eCB), 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in
the brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of …
the brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of …
Mass Spectrometry–Based Proteomics Analysis of Human Substantia Nigra From Parkinson's Disease Patients Identifies Multiple Pathways Potentially Involved in the …
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …
Human striatal glia differentially contribute to AD-and PD-specific neurodegeneration
The commonalities and differences in cell-type-specific pathways that lead to Alzheimer
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single …
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single …
[HTML][HTML] Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology
As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …
neuroscientists studying a wide gamut of brain regions have discovered remarkable …
Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy
SN Fox, LJ McMeekin, CH Savage, KL Joyce… - npj Parkinson's …, 2022 - nature.com
Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in
Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from …
Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from …
Monoterpenoid epoxidiol ameliorates the pathological phenotypes of the rotenone-induced Parkinson's disease model by alleviating mitochondrial dysfunction
Y Aleksandrova, K Chaprov, A Podturkina… - International journal of …, 2023 - mdpi.com
Parkinson's disease is the second most common neurodegenerative disease. Unfortunately,
there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian …
there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian …
[PDF][PDF] Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake
R Melani, NX Tritsch - Cell reports, 2022 - cell.com
Dopamine (DA)-releasing neurons in the substantia nigra pars compacta (SNc DA) inhibit
target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) …
target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) …