Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Intermittent fasting (IF) protects against the development of metabolic diseases and cancer,
but whether it can prevent diabetic microvascular complications is not known. In db/db mice …

Abstract Introduction Bile acids (BAs) are the end products of cholesterol metabolism
produced by human and gut microbiome co-metabolism. Recent evidence suggests gut …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Mitochondrial control of cell death | Nature Medicine Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Several studies have characterized the cellular and molecular mechanisms of hepatocyte
injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

The dynamic and multiple functions of p53, together with its involvement in the most
common non-infectious diseases, underscore the need to elucidate the complexity of the …