Desmosomes as signaling hubs in the regulation of cell behavior

L Müller, M Hatzfeld, R Keil - Frontiers in cell and developmental …, 2021 - frontiersin.org
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic
and stress conditions. These functions rely on their unique structural properties, which …

Revisiting the embryogenesis of lip and palate development

NL Hammond, MJ Dixon - Oral Diseases, 2022 - Wiley Online Library
Clefts of the lip and palate (CLP), the major causes of congenital facial malformation
globally, result from failure of fusion of the facial processes during embryogenesis. With a …

Urinary biomarkers of brain diseases

M An, Y Gao - Genomics, Proteomics and Bioinformatics, 2015 - academic.oup.com
Biomarkers are the measurable changes associated with a physiological or
pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms …

Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation

EN Kouwenhoven, M Oti, H Niehues… - EMBO …, 2015 - embopress.org
The transcription factor p63 plays a pivotal role in keratinocyte proliferation and
differentiation in the epidermis. However, how p63 regulates epidermal genes during …

SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin

G Ferone, JY Song, KD Sutherland, R Bhaskaran… - Cancer cell, 2016 - cell.com
Lung squamous cell carcinoma (LSCC) is a devastating malignancy with no effective
treatments, due to its complex genomic profile. Therefore, preclinical models mimicking its …

Keratins control intercellular adhesion involving PKC-α–mediated desmoplakin phosphorylation

C Kröger, F Loschke, N Schwarz, R Windoffer… - Journal of Cell …, 2013 - rupress.org
Maintenance of epithelial cell adhesion is crucial for epidermal morphogenesis and
homeostasis and relies predominantly on the interaction of keratins with desmosomes …

Desmosomes: regulators of cellular signaling and adhesion in epidermal health and disease

JL Johnson, NA Najor… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

GP Dotto - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
It is increasingly evident that cancer results from altered organ homeostasis rather than from
deregulated control of single cells or groups of cells. This applies especially to epithelial …

A miR‐34a‐SIRT6 axis in the squamous cell differentiation network

K Lefort, Y Brooks, P Ostano, M Cario‐André… - The EMBO …, 2013 - embopress.org
Squamous cell carcinomas (SCCs) are highly heterogeneous tumours, resulting from
deranged expression of genes involved in squamous cell differentiation. Here we report that …

[HTML][HTML] Mechanistic basis of desmosome-targeted diseases

C Al-Jassar, H Bikker, M Overduin… - Journal of molecular …, 2013 - Elsevier
Desmosomes are dynamic junctions between cells that maintain the structural integrity of
skin and heart tissues by withstanding shear forces. Mutations in component genes cause …