5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

During pregnancy, the energy requirements of the fetus impose changes in maternal
metabolism. Increasing insulin resistance in the mother maintains nutrient flow to the …

The majority of the body's serotonin (5‐HT) is produced by the gastrointestinal tract. 5‐HT
has several functions in the gastrointestinal tract. 5‐HT is a paracrine signalling molecule …

Background & Aims: Interstitial cells of Cajal (ICC) are required for normal gastrointestinal
motility. Loss of ICC is associated with several motility disorders. The mechanisms …

Abstract The serotonin 2B receptor (5-HT 2B R), which was first cloned and characterized in
the rat stomach fundus, is the most recent addition to the 5-HT 2 R family. While its …

Background Normal gastrointestinal motility requires intact networks of interstitial cells of
Cajal (ICC). Interstitial cells of Cajal numbers are maintained by a balance between cell loss …

Programmed cell death is a well established key process required for proper development of
the nervous system. The regulatory and executor mechanisms controlling survival/death of …

Serotonin (5-HT) is a neuromodulator that plays many different roles in adult and embryonic
life. Among the 5-HT receptors, 5-HT2B is one of the key mediators of 5-HT functions during …

A forward chemical genomic screen was carried out using Xenopus laevis embryos to
identify compounds disrupting pigmented cell development, including the retinal pigment …

Planaria is an ideal system to study factors involved in regeneration and tissue homeostasis.
Little is known about the role of metabolites and small molecules in stem cell maintenance …