40 years of IGF1: IGF1 receptor signaling pathways
F Hakuno, SI Takahashi - Journal of molecular endocrinology, 2018 - jme.bioscientifica.com
Insulin-like growth factors (IGFs) bind specifically to the IGF1 receptor on the cell surface of
targeted tissues. Ligand binding to the α subunit of the receptor leads to a conformational …
targeted tissues. Ligand binding to the α subunit of the receptor leads to a conformational …
The somatomedin hypothesis: 2001
Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …
discoveries have allowed investigators to modify the concept. Originally somatic growth was …
Structure and function of the type 1 insulin-like growth factor receptor
TE Adams, VC Epa, TPJ Garrett, CW Ward* - Cellular and Molecular Life …, 2000 - Springer
The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is
widely expressed across many cell types in foetal and postnatal tissues. Activation of the …
widely expressed across many cell types in foetal and postnatal tissues. Activation of the …
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis
F Peruzzi, M Prisco, M Dews, P Salomoni… - … and cellular biology, 1999 - Am Soc Microbiol
The type 1 insulin-like growth factor receptor (IGF-1R), activated by its ligands, protects
several cell types from a variety of apoptotic injuries. The main signaling pathway for IGF-1R …
several cell types from a variety of apoptotic injuries. The main signaling pathway for IGF-1R …
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
JP Borg, J Ooi, E Levy, B Margolis - Molecular and cellular biology, 1996 - Am Soc Microbiol
The phosphotyrosine interaction (PI) domains (also known as the PTB, or phosphotyrosine
binding, domains) of Shc and IRS-1 are recently described domains that bind peptides …
binding, domains) of Shc and IRS-1 are recently described domains that bind peptides …
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder
We present a new strategy for systematic identification of phosphotyrosine (pTyr) by affinity
purification mass spectrometry (AP-MS) using a Src homology 2 (SH2)-domain-derived pTyr …
purification mass spectrometry (AP-MS) using a Src homology 2 (SH2)-domain-derived pTyr …
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation
L Girnita, C Worrall, SI Takahashi, S Seregard… - Cellular and molecular …, 2014 - Springer
The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …
and progression of cancer; however, therapeutics targeting it have had disappointing results …
The IGF system and breast cancer.
D Sachdev, D Yee - Endocrine-related cancer, 2001 - erc.bioscientifica.com
The IGF system components have been implicated in breast cancer progression. IGF-I and
IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell …
IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell …
Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology
The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and
IGF-II. The IGFs play a critical role in promoting development, stimulating growth and …
IGF-II. The IGFs play a critical role in promoting development, stimulating growth and …
Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes
R Foncea, M Andersson, A Ketterman… - Journal of Biological …, 1997 - ASBMB
In response to insulin-like growth factor-I (IGF-I), neonatal rat cardiac myocytes exhibit a
hypertrophic response. The elucidation of the IGF-I signal transduction system in these cells …
hypertrophic response. The elucidation of the IGF-I signal transduction system in these cells …