Insulin-like growth factors (IGFs) bind specifically to the IGF1 receptor on the cell surface of
targeted tissues. Ligand binding to the α subunit of the receptor leads to a conformational …

Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …

The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is
widely expressed across many cell types in foetal and postnatal tissues. Activation of the …

The type 1 insulin-like growth factor receptor (IGF-1R), activated by its ligands, protects
several cell types from a variety of apoptotic injuries. The main signaling pathway for IGF-1R …

The phosphotyrosine interaction (PI) domains (also known as the PTB, or phosphotyrosine
binding, domains) of Shc and IRS-1 are recently described domains that bind peptides …

We present a new strategy for systematic identification of phosphotyrosine (pTyr) by affinity
purification mass spectrometry (AP-MS) using a Src homology 2 (SH2)-domain-derived pTyr …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

The IGF system components have been implicated in breast cancer progression. IGF-I and
IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell …

The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and
IGF-II. The IGFs play a critical role in promoting development, stimulating growth and …

In response to insulin-like growth factor-I (IGF-I), neonatal rat cardiac myocytes exhibit a
hypertrophic response. The elucidation of the IGF-I signal transduction system in these cells …