The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

JT Stapleton, S Foung, AS Muerhoff… - Journal of general …, 2011 - microbiologyresearch.org
In 1967, it was reported that experimental inoculation of serum from a surgeon (GB) with
acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family …

GB virus C: the good boy virus?

N Bhattarai, JT Stapleton - Trends in microbiology, 2012 - cell.com
GB virus C (GBV-C) is a lymphotropic human virus discovered in 1995 that is related to
hepatitis C virus (HCV). GBV-C infection has not been convincingly associated with any …

Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication

Y Yu, Z Wan, JH Wang, X Yang, C Zhang - Virulence, 2022 - Taylor & Francis
ABSTRACT Human pegivirus (HPgV-1), previously known as GB virus C (GBV-C) or
hepatitis G virus (HGV), is a single-stranded positive RNA virus belonging to the genus …

Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MlP-lα, MIP-1β, and SDF-1

J Xiang, SL George, S Wünschmann, Q Chang… - The Lancet, 2004 - thelancet.com
Background People coinfected with HIV and GB virus C (GBV-C) have lower mortality than
HIV-positive individuals without GBV-C infection. HIV uses either of the chemokine receptors …

Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection

ET Chivero, JT Stapleton - Journal of General Virology, 2015 - microbiologyresearch.org
Human pegivirus (HPgV; originally called GB virus C/hepatitis G virus) is an RNA virus
within the genus Pegivirus of the family Flaviviridae that commonly causes persistent …

Human pegivirus type 1: a common human virus that is beneficial in immune-mediated disease?

JT Stapleton - Frontiers in immunology, 2022 - frontiersin.org
Two groups identified a novel human flavivirus in the mid-1990s. One group named the virus
hepatitis G virus (HGV) and the other named it GB Virus type C (GBV-C). Sequence …

Human pegivirus RNA is found in multiple blood mononuclear cells in vivo and serum-derived viral RNA-containing particles are infectious in vitro

ET Chivero, N Bhattarai, RT Rydze… - Journal of General …, 2014 - microbiologyresearch.org
Human pegivirus (HPgV; previously called GB virus C/hepatitis G virus) has limited
pathogenicity, despite causing persistent infection, and is associated with prolonged survival …

GB virus C replicates in primary T and B lymphocytes

SL George, D Varmaz… - The Journal of infectious …, 2006 - academic.oup.com
Abstract GB virus C (GBV-C) infection is common in humans and may persist for decades,
although most infected persons clear the virus and subsequently develop antibodies to the …

Human pegivirus infection and lymphoma risk: A systematic review and meta-analysis

A Fama, MC Larson, BK Link… - Clinical Infectious …, 2020 - academic.oup.com
Abstract Background Human pegivirus (HPgV) is a single-strand RNA virus belonging to the
Flaviviridae. Although no definitive association between HPgV infection and disease has …

Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition

Y Koedel, K Eissmann, H Wend, B Fleckenstein… - Journal of …, 2011 - Am Soc Microbiol
The nonpathogenic human GB virus C (GBV-C), a member of the Flaviviridae, is highly
prevalent in individuals with HIV-1 infections or with parenteral and sexual risk factors. Long …