Induction immunosuppression is intense, prophylactic therapy used at the time of
transplantation based on the empiric observation that more powerful immunosuppression is …

The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing
randomly generated T cell receptors (TCR) and by a series of developmental and selection …

T lymphocytes (T cells) orchestrate adaptive immune responses that clear pathogens from
infected hosts. T cells recognize short peptides (p) derived from antigenic proteins bound to …

There are three classic liver diseases with probable autoimmune etiology: primary biliary
cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. The occurrence of these …

Highlights•Developing vaccines against mutating pathogens is very challenging.•Two
theories were suggested: sequential versus simultaneous immunization.•Multi-strain in silico …

This thesis explores the design and application of artificial immune systems (AISs), problem-
solving systems inspired by the human and other immune systems. AISs to date have largely …

Among various possible causes of autoimmune disease, an important role is played by
infections that can result in a breakdown of immune tolerance, primarily through the …

One of the fundamental properties of the immune system is its capacity to avoid autoimmune
diseases. The mechanism underlying this process, known as self-tolerance, is hitherto …

Summary 'It's high time molecular biology became quantitative, it cries out to a physicist… for
modeling. Modeling isn't a crutch, it's the opposite; it's a way of suggesting experiments to …

Predicting the virulence of new Influenza strains is an important problem. The solution to this
problem will likely require a combination of in vitro and in silico tools that are used iteratively …