N‐methylation in amino acids and peptides: Scope and limitations
Active pharmaceutical ingredients (APIs) can be divided into two types, namely chemical
and biological entities. Traditionally, the former has been associated with the so‐called …
and biological entities. Traditionally, the former has been associated with the so‐called …
Fluorescein and rhodamine B-binding domains from autodisplayed Fv-antibody library
J Jung, JH Bong, JS Sung, SJ Lee, M Lee… - Bioconjugate …, 2021 - ACS Publications
In this study, the binding domains for fluorescent dyes were presented that could be used as
synthetic peptides or fusion proteins. Fv-antibodies against two fluorescent dyes (fluorescein …
synthetic peptides or fusion proteins. Fv-antibodies against two fluorescent dyes (fluorescein …
A smart tumor targeting peptide–drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells
Q Song, X Chuan, B Chen, B He, H Zhang, W Dai… - Drug …, 2016 - Taylor & Francis
Doxorubicin (DOX) is a potent anticancer drug for the treatment of tumors, but the poor
specificity and multi-drug resistance (MDR) on tumor cells have restricted its application …
specificity and multi-drug resistance (MDR) on tumor cells have restricted its application …
Exploring a Solvent Dependent Strategy to Control Self‐Assembling Behavior and Cellular Interaction in Laminin‐Mimetic Short Peptide based Supramolecular …
Self‐assembled hydrogels, fabricated through diverse non‐covalent interactions, have been
extensively studied in regenerative medicines. Inspired from bioactive functional motifs of …
extensively studied in regenerative medicines. Inspired from bioactive functional motifs of …
Amino acids bearing aromatic or heteroaromatic substituents as a new class of ligands for the lysosomal sialic acid transporter sialin
L Dubois, N Pietrancosta, A Cabaye… - Journal of Medicinal …, 2020 - ACS Publications
Sialin, encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in
Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of …
Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of …
[HTML][HTML] N-Acetyl-l-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of Anti-Inflammatory 2-(N-Acetyl)-l-phenylalanylamido-2 …
A thorough study on the amidation conditions of N-acetyl-l-phenylalanine using TBTU and
various bases is reported for the synthesis of 2-(N-acetyl)-l-phenylalanylamido-2-deoxy-d …
various bases is reported for the synthesis of 2-(N-acetyl)-l-phenylalanylamido-2-deoxy-d …
Chemosensitization of non-small cell lung cancer to sorafenib via non-hydroxamate s-triazinedione-based MMP-9/10 inhibitors
HH Khalil, MM El-Sheshtawy, SN Khattab… - Bioorganic …, 2024 - Elsevier
Non-small cell lung cancer (NSCLC) continues to be a leading cause of cancer death. Its
fatality is associated with angiogenesis and metastasis. While VEGFR inhibitors are …
fatality is associated with angiogenesis and metastasis. While VEGFR inhibitors are …
[HTML][HTML] Antioxidant and anti-aging potential of a peptide formulation (Gal 2–Pep) conjugated with gallic acid
Skin is highly vulnerable to premature aging due to external stress, therefore, in this study, a
peptide formulation,(galloyl) 2–KTPPTTP (Gal2–Pep) was synthesized by combining …
peptide formulation,(galloyl) 2–KTPPTTP (Gal2–Pep) was synthesized by combining …
In Vitro Biochemical Characterization of Excised Macrocyclizing Thioesterase Domains from Non-ribosomal Peptide Synthetases
JT Brazeau-Henrie, AR Paquette, CN Boddy - Non-Ribosomal Peptide …, 2023 - Springer
Abstract Characterization of thioesterases (TEs) is an important step in understanding
natural product biosynthesis. Studying non-ribosomal peptide synthetase (NRPS) TEs …
natural product biosynthesis. Studying non-ribosomal peptide synthetase (NRPS) TEs …
Synthesis, SAR and biological studies of sugar amino acid-based almiramide analogues: N-methylation leads the way
D Das, HPA Khan, R Shivahare, S Gupta… - Organic & …, 2017 - pubs.rsc.org
Leishmaniasis, caused by the protozoan parasites of the genus Leishmania, is one of the
most neglected diseases endemic in many continents posing enormous global health …
most neglected diseases endemic in many continents posing enormous global health …