Raptinal: a powerful tool for rapid induction of apoptotic cell death
AJ Smith, PJ Hergenrother - Cell Death Discovery, 2024 - nature.com
Chemical inducers of apoptosis have been utilized for decades as tools to uncover steps of
the apoptotic cascade and to treat various diseases, most notably cancer. While there are …
the apoptotic cascade and to treat various diseases, most notably cancer. While there are …
Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation
BS Saller, S Wöhrle, L Fischer, C Dufossez, IL Ingerl… - Immunity, 2024 - cell.com
How mitochondria reconcile roles in functionally divergent cell death pathways of apoptosis
and NLRP3 inflammasome-mediated pyroptosis remains elusive, as is their precise role in …
and NLRP3 inflammasome-mediated pyroptosis remains elusive, as is their precise role in …
cfGWAS reveal genetic basis of cell-free DNA features
H Zhu, Y Zhang, S Zeng, L Li, R Ou, X Zhang, Y Lin… - medRxiv, 2024 - medrxiv.org
cfDNA consists of degraded DNA fragments released into body fluids. Its genetic and
pathological information makes it useful for prenatal testing and early tumor detection …
pathological information makes it useful for prenatal testing and early tumor detection …
Novel naphthyridones targeting pannexin 1 for colitis management
WY Hsueh, YL Wu, MT Weng, SY Liu, JP Santavanond… - bioRxiv, 2024 - biorxiv.org
Pannexin 1 (PANX1) forms cell-surface channels capable of releasing signaling metabolites
for diverse patho-physiological processes. While inhibiting dysregulated PANX1 is proposed …
for diverse patho-physiological processes. While inhibiting dysregulated PANX1 is proposed …