Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy
Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …
Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer
The initiation of the" nanotechnology era" within the past decade has been prominently
marked by advancements in biomaterials. This intersection has opened up numerous …
marked by advancements in biomaterials. This intersection has opened up numerous …
Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
Controlling nanocarrier interactions with the immune system requires a thorough
understanding of the surface properties that modulate protein adsorption in biological fluids …
understanding of the surface properties that modulate protein adsorption in biological fluids …
Engineering endosomolytic nanocarriers of diverse morphologies using confined impingement jet mixing
The clinical translation of many biomolecular therapeutics has been hindered by
undesirable pharmacokinetic (PK) properties, inadequate membrane permeability, poor …
undesirable pharmacokinetic (PK) properties, inadequate membrane permeability, poor …
The combination of morphology and surface chemistry defines the immunological identity of nanocarriers in human blood
Upon exposure to blood, a corona of proteins adsorbs to nanocarrier surfaces to confer a
biological identity that interfaces with the immune system. While the nanocarrier surface …
biological identity that interfaces with the immune system. While the nanocarrier surface …
Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off–on cytotoxicity
Bicontinuous nanospheres (BCNs) are underutilized self-assembled nanostructures
capable of simultaneous delivery of both hydrophilic and hydrophobic payloads. Here, we …
capable of simultaneous delivery of both hydrophilic and hydrophobic payloads. Here, we …
Magnetic nanostructure-loaded bicontinuous nanospheres support multicargo intracellular delivery and oxidation-responsive morphological transitions
Magnetic nanostructures (MNS) have a wide range of biological applications due to their
biocompatibility, superparamagnetic properties, and customizable composition that includes …
biocompatibility, superparamagnetic properties, and customizable composition that includes …
Surface engineering of FLT4-targeted nanocarriers enhances cell-softening glaucoma therapy
MP Vincent, T Stack, A Vahabikashi, G Li… - … applied materials & …, 2021 - ACS Publications
Primary open-angle glaucoma is associated with elevated intraocular pressure (IOP) that
damages the optic nerve and leads to gradual vision loss. Several agents that reduce the …
damages the optic nerve and leads to gradual vision loss. Several agents that reduce the …
Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells
Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger
genetic elements, including" all-in-one" CRISPR/Cas9 plasmids, but is limited by toxicity as …
genetic elements, including" all-in-one" CRISPR/Cas9 plasmids, but is limited by toxicity as …
The combination of morphology and surface chemistry defines the biological identity of nanocarriers in human blood
Following intravenous administration, an adsorbed corona of blood proteins immediately
forms on the surfaces of nanocarriers to confer a distinct biological identity that dictates …
forms on the surfaces of nanocarriers to confer a distinct biological identity that dictates …