Feynman commented that “Everything that living things do can be understood in terms of the
jiggling and wiggling of atoms”. Proteins can jiggle and wiggle large structural elements …

Single-molecule FRET (smFRET) has become a mainstream technique for studying
biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by …

Highlights•The intrinsic dynamics, encoded in proteins' sequences and structures, are
utilized by stimuli to trigger allosteric and functional actions.•The modes of allosteric actions …

The documentation of plant growth and development requires integrative and scalable
approaches to investigate and spatiotemporally resolve various dynamic processes at …

We discuss some of the practical challenges that one faces in using stochastic
thermodynamics to infer directionality of molecular machines from experimental single …

Since the release of AlphaFold, researchers have actively refined its predictions and
attempted to integrate it into existing pipelines for determining protein structures. These …

Proteins often undergo large-scale conformational transitions, in which secondary and
tertiary structure elements (loops, helices, and domains) change their structures or their …

Allostery is probably the most important concept in the regulation of cellular processes.
Models to explain allostery are plenty. Each sheds light on different aspects but their entirety …

Enzymes play a vital role in life processes; they control chemical reactions and allow
functional cycles to be synchronized. Many enzymes harness large-scale motions of their …

Single molecule Förster resonance energy transfer (smFRET) is a unique biophysical
approach for studying conformational dynamics in biomacromolecules. Photon-by-photon …