The role and mechanisms of action of microRNAs in cancer drug resistance

W Si, J Shen, H Zheng, W Fan - Clinical epigenetics, 2019 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

MicroRNA and alternative mRNA splicing events in cancer drug response/resistance: potent therapeutic targets

R Marima, FZ Francies, R Hull, T Molefi, M Oyomno… - Biomedicines, 2021 - mdpi.com
Cancer is a multifaceted disease that involves several molecular mechanisms including
changes in gene expression. Two important processes altered in cancer that lead to …

Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein

X Cheng, L Zhang, K Zhang, G Zhang, Y Hu… - Annals of the …, 2018 - ard.bmj.com
Objectives Circular RNAs (circRNAs) have been proven to function as competing
endogenous RNAs to interact with microRNAs (miRNAs) and influence the expression of …

A non-invasive liquid biopsy screening of urine-derived exosomes for miRNAs as biomarkers in endometrial cancer patients

A Srivastava, K Moxley, R Ruskin, DN Dhanasekaran… - The AAPS Journal, 2018 - Springer
Exosomes have great potential to serve as a source of diagnostic and prognostic biomarkers
for endometrial cancer (EC). Urine-derived exosomes from patients with EC and patients …

Aerosolized miR-138-5p and miR-200c targets PD-L1 for lung cancer prevention

Q Zhang, J Pan, D Xiong, J Zheng… - Frontiers in …, 2023 - frontiersin.org
The development of chemopreventive strategies with the ability to prevent the progression of
lung lesions to malignant cancers would reduce the mortality and morbidity resulting from …

LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells

R Xu, X Zhu, F Chen, C Huang, K Ai, H Wu… - Cancer cell …, 2018 - Springer
Background The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs
and long ncRNAs, often contribute to the development of cancers. miR-200c functions as a …

The microRNA‑200 family acts as an oncogene in colorectal cancer by inhibiting the tumor suppressor RASSF2

JV Carter, SJ O'brien, JF Burton… - Oncology …, 2019 - spandidos-publications.com
This study aimed to determine whether manipulation of the microRNA‑200 (miR‑200) family
could influence colon adenocarcinoma cell behavior. The miR‑200 family has a significant …

[HTML][HTML] The role of microRNA signature as diagnostic biomarkers in different clinical stages of colorectal cancer

S Eslamizadeh, M Heidari, S Agah… - Cell Journal …, 2018 - ncbi.nlm.nih.gov
Objective Colorectal cancer (CRC) is one of the most common cancers and a major cause of
cancer-related death worldwide. The early diagnosis of colorectal tumors is one of the most …

Ursolic acid suppresses the invasive potential of colorectal cancer cells by regulating the TGF-β1/ZEB1/miR-200c signaling pathway

L Zhang, QY Cai, J Liu, J Peng… - Oncology …, 2019 - spandidos-publications.com
Ursolic acid (UA) is a biologically active compound, commonly used in traditional Chinese
medicine (TCM). It has been reported to exhibit strong anticancer properties against a …

KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer

ZZ Wang, J Yang, BH Jiang, JB Di… - International …, 2018 - spandidos-publications.com
As a mitotic kinesin, kinesin family member 14 (KIF14) has been reported to serve
oncogenic roles in a variety of malignancies; however, its functional role and regulatory …