The hypothesis that the small conducting airways were the major site of obstruction to airflow
in normal lungs was introduced by Rohrer in 1915 and prevailed until Weibel introduced a …

The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

The purpose of this statement is to describe and define the phenotypic abnormalities that
can be identified on visual and quantitative evaluation of computed tomographic (CT) …

Individuals with chronic obstructive pulmonary disease (COPD) and asthma are an
important but poorly characterised group. The genetic determinants of COPD and asthma …

OBJECTIVE. This study evaluates the relationships between quantitative CT (QCT) and
spirometric measurements of disease severity in cigarette smokers with and without chronic …

The small airways are defined as those less than 2 mm in diameter. They are a major site of
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow
limitation caused by emphysema and/or airway narrowing. Computed tomography has been …

The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …

Rationale: It is unclear whether airway wall thickening and emphysema make independent
contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and …

Rationale: There is limited knowledge of the prognostic value of quantitative computed
tomography (CT) measures of emphysema and airway wall thickness (AWT) on mortality …