The σ2 receptor has attracted intense interest in cancer imaging, psychiatric disease,
neuropathic pain,–and other areas of biology,. Here we determined the crystal structure of …

Abstract Sigma 1 receptor (σ 1 receptor) is a unique ligand-regulated molecular chaperone
located mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is …

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …

The sigma 2 receptor (σ2R) was described pharmacologically more than three decades ago,
but its molecular identity remained obscure until recently when it was identified as …

BACKGROUND AND PURPOSE The sigma‐1 (σ1) receptor is a ligand‐regulated molecular
chaperone that has been involved in pain, but there is limited understanding of the actions …

The synthesis and pharmacological activity of a new series of 1-arylpyrazoles as potent σ1
receptor (σ1R) antagonists are reported. The new compounds were evaluated in vitro in …

Sigma-1 (σ1) receptors play a role in different types of pain and in central sensitization
mechanisms; however, it is unknown whether they are involved in chemotherapy-induced …

Neuropathic pain is an important medical problem with few effective treatments. The sigma 1
receptor (σ1R) is known to be a potential target for neuropathic pain therapeutics, and …

Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the
neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by …

The sigma-2 receptor has been cloned and identified as Tmem97, which is a
transmembrane protein involved in intracellular Ca 2+ regulation and cholesterol …