Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy

Y Cheng, Y Wang, R Yin, Y Xu, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can
eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis …

Effect of growth hormone on insulin signaling

R Sharma, JJ Kopchick, V Puri, VM Sharma - Molecular and cellular …, 2020 - Elsevier
Growth hormone (GH) is a pleiotropic hormone that coordinates an array of physiological
processes, including effects on bone, muscle, and fat, ultimately resulting in growth …

Obesity associated disease risk: the role of inherent differences and location of adipose depots

JH Hill, C Solt, MT Foster - Hormone molecular biology and clinical …, 2018 - degruyter.com
Obesity and associated metabolic co-morbidities are a worldwide public health problem.
Negative health outcomes associated with obesity, however, do not arise from excessive …

New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients

X Su, Y Kong, D Peng - Lipids in Health and Disease, 2018 - Springer
Abstract Apolipoprotein A5 (apoA5) has been identified to play an important role in lipid
metabolism, specifically in triglyceride (TG) and TG-rich lipoproteins (TRLs) metabolism …

[HTML][HTML] Small intestine-specific knockout of CIDEC improves obesity and hepatic steatosis by inhibiting synthesis of phosphatidic acid

L Huang, Q Liao, T Pan, Y Sun, Z Aluo… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The small intestine is main site of exogenous lipid digestion and absorption, and it is
important for lipid metabolic homeostasis. Cell death-inducing DNA fragmentation-factor like …

Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: gaps and open questions

M Ruscica, A Baragetti, AL Catapano… - Nutrition, Metabolism and …, 2017 - Elsevier
Aim Critically discuss the available data, to identify the current gaps and to provide key
concepts that will help clinicians in translating the biology of adipokines in the context of …

Characteristics and molecular mechanisms through which SGLT2 inhibitors improve metabolic diseases: A mechanism review

X Lingli, X Wenfang - Life Sciences, 2022 - Elsevier
Metabolic diseases, such as diabetes, gout and hyperlipidemia are global health
challenges. Among them, diabetes has been extensively investigated. Type 2 diabetes …

Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes

VM Sharma, ET Vestergaard… - American Journal …, 2019 - journals.physiology.org
The lipolytic effects of growth hormone (GH) have been known for half a century and play an
important physiological role for substrate metabolism during fasting. In addition, sustained …

Adipose tissue at the nexus of systemic and cellular immunometabolism

AC Kohlgruber, NM LaMarche, L Lynch - Seminars in immunology, 2016 - Elsevier
At the simplest interpretation of the word, Immunometabolism describes the intersection of
the fields of immunology and metabolism. With rapidly growing interest in this field, the term …

CIDE proteins in human health and disease

M Slayton, A Gupta, B Balakrishnan, V Puri - Cells, 2019 - mdpi.com
Cell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins
have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are …