Molecular and nanoengineering approaches towards activatable cancer immunotherapy
C Zhang, K Pu - Chemical Society Reviews, 2020 - pubs.rsc.org
Cancer immunotherapy is an emerging treatment strategy that modulates the immune
system to fight against cancer. Although several immunotherapeutic agents have been …
system to fight against cancer. Although several immunotherapeutic agents have been …
Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control
L Lu, M Xie, B Yang, W Zhao, J Cao - Science Advances, 2024 - science.org
Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted
therapy for cancer that has demonstrated notable potential in clinical applications. However …
therapy for cancer that has demonstrated notable potential in clinical applications. However …
A small and highly sensitive red/far-red optogenetic switch for applications in mammals
Y Zhou, D Kong, X Wang, G Yu, X Wu, N Guan… - Nature …, 2022 - nature.com
Optogenetic technologies have transformed our ability to precisely control biological
processes in time and space. Yet, current eukaryotic optogenetic systems are limited by …
processes in time and space. Yet, current eukaryotic optogenetic systems are limited by …
Immunotherapy for malignant glioma: current status and future directions
Glioma is the most common intracranial primary malignancy, with limited treatment options
and a poor overall survival (OS). Immunotherapy has been used successfully in various …
and a poor overall survival (OS). Immunotherapy has been used successfully in various …
Engineering AraC to make it responsive to light instead of arabinose
E Romano, A Baumschlager, EB Akmeric… - Nature chemical …, 2021 - nature.com
The l-arabinose-responsive AraC and its cognate PBAD promoter underlie one of the most
often used chemically inducible prokaryotic gene expression systems in microbiology and …
often used chemically inducible prokaryotic gene expression systems in microbiology and …
Chemoattractant receptors BLT1 and CXCR3 regulate antitumor immunity by facilitating CD8+ T cell migration into tumors
Immunotherapies have shown considerable efficacy for the treatment of various cancers, but
a multitude of patients remain unresponsive for various reasons, including poor homing of T …
a multitude of patients remain unresponsive for various reasons, including poor homing of T …
Optophysiology: Illuminating cell physiology with optogenetics
Optogenetics combines light and genetics to enable precise control of living cells, tissues,
and organisms with tailored functions. Optogenetics has the advantages of …
and organisms with tailored functions. Optogenetics has the advantages of …
Adoptive T‐cell therapy for cancer: The era of engineered T cells
Tumors originate from a number of genetic events that deregulate homeostatic mechanisms
controlling normal cell behavior. The immune system, devoted to patrol the organism against …
controlling normal cell behavior. The immune system, devoted to patrol the organism against …
Light‐controlled mammalian cells and their therapeutic applications in synthetic biology
M Mansouri, T Strittmatter, M Fussenegger - Advanced Science, 2019 - Wiley Online Library
The ability to remote control the expression of therapeutic genes in mammalian cells in order
to treat disease is a central goal of synthetic biology‐inspired therapeutic strategies …
to treat disease is a central goal of synthetic biology‐inspired therapeutic strategies …
Optogenetic immunomodulation: shedding light on antitumor immunity
Microbial opsin-based optogenetic tools have been transformative for neuroscience. To
extend optogenetic approaches to the immune system to remotely control immune …
extend optogenetic approaches to the immune system to remotely control immune …