Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Low-protein diets promote metabolic health in rodents and humans, and the benefits of low-
protein diets are recapitulated by specifically reducing dietary levels of the three branched …

The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Background Obesity develops due to an imbalance in energy homeostasis, wherein energy
intake exceeds energy expenditure. Accumulating evidence shows that manipulations of …

Key points We recently found that feeding healthy mice a diet with reduced levels of
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both …

Low-protein diets promote metabolic health in humans and rodents. Despite evidence that
sex and genetic background are key factors in the response to diet, most protein intake …

Integrated immunometabolic responses link dietary intake, energy utilization, and storage to
immune regulation of tissue function and is therefore essential for the maintenance and …

For the past five decades, the lysosome has been characterized as an unglamorous cellular
recycling center. This notion has undergone a radical shift in the last 10 years, with new …