The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation

T Napso, HEJ Yong, J Lopez-Tello… - Frontiers in …, 2018 - frontiersin.org
During pregnancy, the mother must adapt her body systems to support nutrient and oxygen
supply for growth of the baby in utero and during the subsequent lactation. These include …

[HTML][HTML] Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder

M Sgritta, SW Dooling, SA Buffington, EN Momin… - Neuron, 2019 - cell.com
Currently, there are no medications that effectively treat the core symptoms of Autism
Spectrum Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) …

Oxytocin receptor is not required for social attachment in prairie voles

KM Berendzen, R Sharma, MA Mandujano, Y Wei… - Neuron, 2023 - cell.com
Prairie voles are among a small group of mammals that display long-term social attachment
between mating partners. Many pharmacological studies show that signaling via the …

Gating of social reward by oxytocin in the ventral tegmental area

LW Hung, S Neuner, JS Polepalli, KT Beier, M Wright… - Science, 2017 - science.org
The reward generated by social interactions is critical for promoting prosocial behaviors.
Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a …

[HTML][HTML] Neurobiology and consequences of social isolation stress in animal model—A comprehensive review

F Mumtaz, MI Khan, M Zubair, AR Dehpour - Biomedicine & …, 2018 - Elsevier
The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

J Wahis, A Baudon, F Althammer, D Kerspern… - Nature …, 2021 - nature.com
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural
circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby …

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

G Dölen, A Darvishzadeh, KW Huang, RC Malenka - Nature, 2013 - nature.com
Social behaviours in species as diverse as honey bees and humans promote group survival
but often come at some cost to the individual. Although reinforcement of adaptive social …

Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior

KM Dumais, AH Veenema - Frontiers in neuroendocrinology, 2016 - Elsevier
The neuropeptides vasopressin (VP) and oxytocin (OT) and their receptors in the brain are
involved in the regulation of various social behaviors and have emerged as drug targets for …

The neurobiology of anhedonia and other reward-related deficits

A Der-Avakian, A Markou - Trends in neurosciences, 2012 - cell.com
Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major
depression, schizophrenia and other neuropsychiatric disorders. Over the past three …