The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy
Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic
acids and mediate intercellular communication among multiple cells in the tumour …
acids and mediate intercellular communication among multiple cells in the tumour …
Novel approaches in cancer treatment: preclinical and clinical development of small non-coding RNA therapeutics
R Cuciniello, S Filosa, S Crispi - Journal of Experimental & Clinical Cancer …, 2021 - Springer
Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in
size and function able to inhibit gene expression based on their complementarity with mRNA …
size and function able to inhibit gene expression based on their complementarity with mRNA …
Liquid biopsies to occult brain metastasis
Brain metastasis (BrM) is a major problem associated with cancer-related mortality, and
currently, no specific biomarkers are available in clinical settings for early detection. Liquid …
currently, no specific biomarkers are available in clinical settings for early detection. Liquid …
Pharmaceutical Strategies for Optimized mRNA Expression
Y Shi, J Mao, S Wang, S Ma, L Luo, J You - Biomaterials, 2024 - Elsevier
Messenger RNA (mRNA)-based immunotherapies and protein in situ production therapies
hold great promise for addressing theoretically all the diseases characterized by aberrant …
hold great promise for addressing theoretically all the diseases characterized by aberrant …
Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid …
EY Lin, SX Hsu, BH Wu, YC Deng, W Wuli… - International Journal …, 2024 - Taylor & Francis
Purpose Exosomes are membrane vesicles secreted by various cells and play a crucial role
in intercellular communication. They can be excellent delivery vehicles for oligonucleotide …
in intercellular communication. They can be excellent delivery vehicles for oligonucleotide …
Medical Use of mRNA-Based Directed Gene Delivery
AC Matin, A Forterre - Messenger RNA Therapeutics, 2022 - Springer
Systemically administered targeted gene therapy can benefit many diseases. This chapter
focuses on mRNA-mediated gene delivery. We discuss why mRNA is superior to DNA for …
focuses on mRNA-mediated gene delivery. We discuss why mRNA is superior to DNA for …