Cellular specificity of NF-κB function in the nervous system

EC Dresselhaus, MK Meffert - Frontiers in immunology, 2019 - frontiersin.org
Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key
functions in a wide array of biological systems. While the role of NF-κB in processes, such as …

Neuroinflammation as a factor of neurodegenerative disease: thalidomide analogs as treatments

YJ Jung, D Tweedie, MT Scerba… - Frontiers in Cell and …, 2019 - frontiersin.org
Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to
the neural environment, such as pathogen infiltration or neuronal injury. Although …

B cells in neuroinflammation: new perspectives and mechanistic insights

JJ Ahn, M Abu-Rub, RH Miller - Cells, 2021 - mdpi.com
In recent years, the role of B cells in neurological disorders has substantially expanded our
perspectives on mechanisms of neuroinflammation. The success of B cell-depleting …

In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP)

M Ma, S Huo, M Zhang, S Qian, X Zhu, J Pu… - Nature …, 2022 - nature.com
Accurate, in-depth mapping of proteins on whole-tissue levels provides comprehensive
insights into the spatially-organized regulatory processes/networks in tissues, but is …

Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation

JD Hill, V Zuluaga-Ramirez, S Gajghate… - Brain, behavior, and …, 2019 - Elsevier
New neurons are continuously produced by neural stem cells (NSCs) within the adult
hippocampus. Numerous diseases, including major depressive disorder and HIV-1 …

RelB and neuroinflammation

K Mockenhaupt, A Gonsiewski, T Kordula - Cells, 2021 - mdpi.com
Neuroinflammation within the central nervous system involves multiple cell types that
coordinate their responses by secreting and responding to a plethora of inflammatory …

Circadian rhythm disruption modulates enteric neural precursor cells differentiation leading to gastrointestinal motility dysfunction via the NR1D1/NF-κB axis

Y Zhang, S Xu, M Fan, H Yao, C Jiang, Q He… - Journal of translational …, 2024 - Springer
Objectives Circadian rhythm disruption (CRD) is implicated with numerous gastrointestinal
motility diseases, with the enteric nervous system (ENS) taking main responsibility for the …

Helicobacter and the Potential Role in Neurological Disorders: There Is More Than Helicobacter pylori

N Gorlé, E Bauwens, F Haesebrouck, A Smet… - Frontiers in …, 2021 - frontiersin.org
Trillions of symbiotic microbial cells colonize our body, of which the larger part is present in
the human gut. These microbes play an essential role in our health and a shift in the …

Single‐cell RNA Seq reveals cellular l andscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis

Y Yang, M Yang, D Shi, K Chen, J Zhao, S He… - JOR …, 2021 - Wiley Online Library
Backgrounds Abnormal vertebral growth and development have been found in adolescent
idiopathic scoliosis (AIS) patients, and the proliferation and differentiation of bone …

In vitro monolayer culture of dispersed neural stem cells on the e-cadherin-based substrate with long-term stemness maintenance

S Yang, Z Cao, J Zhu, Z Zhang, H Zhao, L Zhao… - ACS …, 2019 - ACS Publications
Neural stem cells (NSCs) play an important role in neural tissue engineering because of
their capacity of self-renewal and differentiation to multiple cell lineages. The in vitro …