The accurate segregation of genetic material to daughter cells during mitosis depends on
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …

Abstract Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that
catalyzes the selective removal of phosphate groups from protein serine and threonine …

Impairment of protein phosphatases, including the family of serine/threonine phosphatases
designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The …

SUMMARY Protein phosphatase 2A (PP2A) enzymes can suppress tumors, but they are
often inactivated in human cancers overexpressing inhibitory proteins. Here, we identify a …

The integrated stress response (ISR) regulates cell fate during conditions of stress by
leveraging the cell's capacity to endure sustainable and efficient adaptive stress responses …

Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …

Heart failure remains a major health burden around the world. Despite great progress in
delineation of molecular mechanisms underlying development of disease, standard therapy …

High-grade serous carcinoma (HGSC) is the most common and lethal ovarian cancer
subtype. PARP inhibitors (PARPi) have become the mainstay of HGSC-targeted therapy …

Loss of hepatic fructose-1, 6-bisphosphate aldolase B (Aldob) leads to a paradoxical up-
regulation of glucose metabolism to favor hepatocellular carcinogenesis (HCC), but the …

Therapies targeting tyrosine and serine/threonine kinases have raised enormous interest as
potential cure for cancer patients in many common cancer types. However, except for the …