Abstract Alzheimer's disease (AD), the most common cause of adult-onset dementia is
characterized by a progressive decline of cognitive functions accompanied by behavioral …

Molecular hybridization is a well-exploited medicinal chemistry strategy that aims to combine
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been …

The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …

Communication is very important for people to be successfully integrated into social
environment and make and maintain relationship. Particularly, language difficulties lead to …

Alzheimer's Disease (AD), affecting a large population worldwide is characterized by the
loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase …

Social development, better living conditions and medical advances lead to the fact that more
people have the opportunity to live longer than in the past. The aging population is a …

We report the identification of multitarget anti-Alzheimer compounds designed by combining
a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by memory loss, cognitive impairment, and functional decline leading to dementia and …

Coupling of two distinct pharmacophores, tacrine and trolox, endowed with different
biological properties, afforded 21 hybrid compounds as novel multifunctional candidates …

A combination of tacrine and tryptophan led to the development of a new family of
heterodimers as multi-target agents with potential to treat Alzheimer's disease. Based on the …