Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …

Abstract Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-
membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is …

Adaptive immunity depends on T-cell exit from the thymus and T and B cells travelling
between secondary lymphoid organs to survey for antigens. After activation in lymphoid …

During infections or acute conditions high-density lipoproteins cholesterol (HDL-C) levels
decrease very rapidly and HDL particles undergo profound changes in their composition …

Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are
strategically positioned as immune sentinels poised to respond to invading pathogens in …

Liposomes (phospholipid bilayer vesicles) are versatile and robust delivery systems for
induction of antibody and T lymphocyte responses to associated subunit antigens. In the last …

Sphingolipids, which are components of cellular membranes and organ tissues, can be
synthesized or degraded to modulate cellular responses according to environmental cues …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is critically involved in the
embryonic development of the cardiovascular and central nervous systems. In the adult, S1P …

Abstract Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that
transmits signals through a family of G-protein-coupled receptors to control cellular …

Abstract Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously
expressed. S1P-S1PR signaling has been well characterized in immune trafficking and …