Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

The authors of this review both served on the National Academy of Science, Engineering,
and Medicine Committee that produced the report,“Social Isolation and Loneliness in Older …

Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease
(AD), including prodromal and preclinical, are lacking, yet are needed to inform policy …

There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

Social isolation and loneliness are serious yet underappreciated public health risks that
affect a significant portion of the older adult population. Approximately one-quarter of …

Dementia is a rapidly rising global health crisis that silently disables families and ends lives
and livelihoods around the world. To date, however, no early biomarkers or effective …

Cognitive abilities are important predictors of educational and occupational performance,
socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to …

There is a large and growing body of evidence on the health benefits of engagement in
leisure activities (voluntary, enjoyable non-work activities, such as hobbies, arts …

Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Background: The sudden and drastic changes due to the Coronavirus Disease 19 (COVID-
19) pandemic have impacted people's physical and mental health. Clinically-vulnerable …