The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Characterized by intracellular lipid droplet accumulation, clear cell renal cell carcinoma
(ccRCC) is resistant to cytotoxic chemotherapy and is a lethal disease. Through an unbiased …

Hypoxia is the major influence factor in physiological and pathological courses which are
mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions …

The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists
of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer …

This review examines the impact of reactive species RS (of oxygen ROS, nitrogen RNS and
halogens RHS) on various amino acids, analyzed from a reactive point of view of how during …

Protein arginine methylation is a common post-translational modification involved in
numerous cellular processes including transcription, DNA repair, mRNA splicing and signal …

Highlights•The first wave of potent specific KDM1A inhibitors is currently in Phase I
testing.•The first potent specific KDM5 inhibitor is in preclinical regulatory …

Highlights•Human JmjC domain-containing proteins belong to the 2OG oxygenase
superfamily.•JmjC catalysis enables formation of stable alcohols or demethylation of N …

Jumonji C-domain-containing protein 6 (JMJD6), an iron (Fe2+) and α-ketoglutarate (α-KG)-
dependent oxygenase, is expressed at high levels, correlated with poor prognosis, and …