Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …

The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also
facilitates synaptic transmission, but it is unclear if this facilitation results from pre-and/or …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

In addition to its direct pre-and postsynaptic actions on neurones, adenosine is rich in
nuances of priming, triggering and inhibiting the action of several neurotransmitters and …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

1 In the present work, we investigated the action of adenosine originating from extracellular
catabolism of adenine nucleotides, in two preparations where synaptic transmission is …

Purines are important modulators of bone cell biology. ATP is metabolized into adenosine
by human primary osteoblast cells (HPOC); due to very low activity of adenosine deaminase …

A low concentration (10 nM) of adenosine potentiated hippocampal neuronal activity via A2a
adenosine receptors without affecting presynaptic glutamate release or postsynaptic …

Purine analogues have been examined for anxiolytic-and anxiogenic-like activity in mice, by
use of the elevated plus-maze. 2. The selective A1 receptor agonist, N6 …