Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …

Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently
discovered related molecules are forming a family of cytokines, the IL-17 family. The …

Background: IL-17 is a cytokine that has been reported to be produced by T lymphocytes. In
vitro, IL-17 activates fibro-blasts and macrophages for the secretion of GM-CSF, TNF-α, IL …

Myelin-directed autoimmunity is considered to play a key role in the pathogenesis of multiple
sclerosis (MS). Increased production of both pro-and anti-inflammatory cytokines is a …

Summary Uncommitted (naive) murine CD4+ T helper cells (Thp) can be induced to
differentiate towards T helper 1 (Th1), Th2, Th17 and regulatory (Treg) phenotypes …

T helper 17 (Th17) cells and regulatory T (Treg) cells are two distinct subsets of CD4+ T cells
which have opposite effects on inflammation, autoimmunity and immunological rejection of …

IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The large-
scale sequencing of the human and other vertebrate genomes has revealed the presence of …

The proinflammatory cytokine interleukin 17 (IL‐17) is the founding member of a family of
secreted proteins that elicit potent cellular responses. We report a novel human IL‐17 …

Naive Th cells can be directed in vitro to develop into Th1 or Th2 cells by IL-12 or IL-4,
respectively. In vivo, chronic immune reactions lead to polarized Th cytokine patterns. We …

Since the discovery of interferons over 50 years ago, efforts to understand the biochemistry,
molecular biology and biological activities of cytokines have been intense and rewarding …