Metabolic basis of creatine in health and disease: a bioinformatics-assisted review
Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …
Bioenergetic basis of skeletal muscle fatigue
CW Sundberg, RH Fitts - Current opinion in physiology, 2019 - Elsevier
Highlights•The reliance on anaerobic metabolism causes fatigue during high-intensity
exercise.•Metabolic pathways maintain ATP at levels that do not impair contractile …
exercise.•Metabolic pathways maintain ATP at levels that do not impair contractile …
Bioenergetic mechanisms linking V˙ O2 kinetics and exercise tolerance
• Exceeding this critical threshold causes muscle fatigue and initiation of a positive feedback
loop—a self-driving, reciprocal mechanism of diminishing return—which causes the loss of …
loop—a self-driving, reciprocal mechanism of diminishing return—which causes the loss of …
On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A 31P‐MRS study
TJ Hureau, RM Broxterman, JC Weavil… - The Journal of …, 2022 - Wiley Online Library
Intramuscular hydrogen ion (H+) and inorganic phosphate (Pi) concentrations were
dissociated during exercise to challenge their relationships with peripheral and central …
dissociated during exercise to challenge their relationships with peripheral and central …
[HTML][HTML] Acute high-intensity exercise impairs skeletal muscle respiratory capacity
PURPOSE: The impact of an acute bout of exercise, especially high-intensity exercise, on
the function of mitochondrial respiratory complexes is not well understood, with potential …
the function of mitochondrial respiratory complexes is not well understood, with potential …
“Alternative” fuels contributing to mitochondrial electron transport: Importance of non-classical pathways in the diversity of animal metabolism
The study of glycolysis, the TCA cycle, and oxidative phosphorylation in animals has yielded
a wealth of information about bioenergetics. Less is known about how animals use fuels …
a wealth of information about bioenergetics. Less is known about how animals use fuels …
Caffeine increases both total work performed above critical power and peripheral fatigue during a 4-km cycling time trial
LC Felippe, GA Ferreira, SK Learsi… - Journal of Applied …, 2018 - journals.physiology.org
The link between total work performed above critical power (CP) and peripheral muscle
fatigue during self-paced exercise is unknown. We investigated the influence of caffeine on …
fatigue during self-paced exercise is unknown. We investigated the influence of caffeine on …
Influence of group III/IV muscle afferents on small muscle mass exercise performance: a bioenergetics perspective
Key points This investigation assessed the influence of group III/IV muscle afferents on small
muscle mass exercise performance from a skeletal muscle bioenergetics perspective. Group …
muscle mass exercise performance from a skeletal muscle bioenergetics perspective. Group …
Limb blood flow and muscle oxygenation responses during handgrip exercise above vs. below critical force
This study compared the brachial artery blood flow (Q̇ BA) and microvascular oxygen
delivery responses during handgrip exercise above vs. below critical force (CF; the isometric …
delivery responses during handgrip exercise above vs. below critical force (CF; the isometric …
Central and peripheral factors mechanistically linked to exercise intolerance in heart failure with reduced ejection fraction
Exercise intolerance is a primary symptom of heart failure (HF); however, the specific
contribution of central and peripheral factors to this intolerance is not well described. The …
contribution of central and peripheral factors to this intolerance is not well described. The …