Lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, termed ER-
phagy or reticulophagy, occurs under normal as well as stress conditions. The recent …

Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

The clearance of damaged or unwanted mitochondria by autophagy (also known as
mitophagy) is a mitochondrial quality control mechanism postulated to play an essential role …

Abstract FAM134B (also called JK-1, RETREG1), a member of the family with sequence
similarity 134, was originally discovered as an oncogene in esophageal squamous cell …

Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several
cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can …

Proteostasis is a challenge for cellular organisms, as all known protein synthesis
machineries are error-prone. Here we show by cell fractionation and microscopy studies that …

ABSTRACT Mutations in mitofusin 2 (MFN2) that are associated with the pathology of the
debilitating neuropathy Charcot–Marie–Tooth type 2A (CMT2A) are known to alter …

Purpose To investigate the effect of canagliflozin (20 mg/kg) on hepatic steatosis and
atherosclerosis, and further to explore its possible mechanism. Methods Blood glucose …

There are many cellular mechanisms implicated in the initiation and progression of
neurodegenerative disorders. However, age and the accumulation of unwanted cellular …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a poor
prognosis. As a tumor inhibitor, the specific tumor suppressor mechanism of Sirtuin4 (SIRT4) …